EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRJAK1/2 activated by EGFR kinase domain transactivationSTAT3(Tyr705) phosphorylated by JAK2STAT3 homodimerizes and translocates to nucleusBCL-2 promoter (−1630 to −1427) driven by STAT3BCL-2 mRNA elevatedBCL-XL promoter activated by STAT3BCL-XL protein elevatedBAX/BAK pore formation at mitochondria suppressedcytochrome c release blockedapoptosis

Score: 0.9010 hops

Pathway Hops

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

PROMOTESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers