curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcumin26S proteasome chymotrypsin-like activity inhibited by curcuminSKP2(F-box protein) autoubiquitination and degradation elevatedp27(Kip1) ubiquitination by SCF-SKP2 reducedp27(Kip1) protein levels elevatedCDK2(Thr160) activating phosphorylation reduced by p27 bindingcyclin E/CDK2 complex activity impairedRB(Ser795) hypophosphorylation maintainedG1/S transition blockedcolorectal cancer

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops