EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR activates PI3K-AKT axisAKT phosphorylates and activates IKKαIκBα degraded after Ser32/Ser36 phosphorylationNF-κB translocates to nucleusc-FLIP(L) (CFLAR) transcription elevatedc-FLIP(L) binds FADD at DISCcaspase-8(Asp374) autoprocessing at DISC inhibiteddeath receptor-mediated caspase cascade blockedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers