aspirinCOX-2(Ser516) acetylated by aspirinDHA oxygenated by acetylated-COX-2 to 17R-HDoHE elevated17R-HDoHE converted by 5-LOX to aspirin-triggered resolvin D (AT-RvD1) elevatedGPR32 and FPR2 activated on macrophagesERK1/2(Thr202/Tyr204) phosphorylation transiently elevated then suppressedmacrophage phagocytic capacity for apoptotic neutrophils enhancedpro-inflammatory eicosanoid release curtailedinflammation
Score: 0.908 hops
Pathway Hops
ACETYLATESConfidence: 95%
ACETYLATESConfidence: 95%
INDUCESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers