MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1eNOS(Ser1177) phosphorylated by AMPKnitric oxide (NO) production elevated in endotheliumtumor vasodilatory signaling alteredsGC/cGMP pathway elevated in tumor stromapericyte coverage of tumor vasculature normalizedtumor perfusion normalized and drug delivery alteredCancer
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
CAUSESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
ASSOCIATED WITHConfidence: 95%
CAUSESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree