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Biological Pathway
Cite
curcumin
PI3K(p110α) catalytic activity inhibited
PIP3 generation at plasma membrane reduced
AKT(Thr308/Ser473) phosphorylation reduced
TSC2(Thr1462) phosphorylation reduced
TSC1/TSC2 complex GAP activity toward Rheb restored
Rheb-GTP loading reduced
mTORC1(Raptor complex) activity inhibited
S6K1(Thr389) phosphorylation reduced
4E-BP1(Thr37/Thr46) phosphorylation reduced
cap-dependent translation of cyclin D1 and c-Myc reduced
colorectal cancer
Score: 0.90
11 hops
Pathway Hops
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
ACTIVATES
Confidence: 95%
CAUSES
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree