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Biological Pathway
Cite
Metformin
Metformin-activated AMPK(Thr172) suppresses mTORC1-driven cap-dependent translation
XIAP protein level reduced (translation-dependent survival factor)
XIAP(BIR3 domain) no longer binds caspase-9(Asp315)
caspase-9 activity derepressed
XIAP(BIR2 domain) no longer binds caspase-3(Asp175)
caspase-3 activity derepressed
Metformin elevates ROS → SMAC/DIABLO released from mitochondria
SMAC(IBM motif: AVPI) displaces XIAP(BIR3) from caspase-9
cIAP1/2 auto-ubiquitination accelerated in absence of XIAP scaffolding
cIAP1/2 proteasomal degradation
NIK(MAP3K14) stabilised
non-canonical NF-κB pathway partially activated in tumour immune context
survivin(BIR domain) expression reduced via AMPK/FOXO3a transcriptional repression
caspase-3(Asp175) cleavage unopposed
Cancer
Score: 0.90
15 hops
Pathway Hops
SUPPRESSES
Confidence: 95%
SUPPRESSES
Confidence: 95%
INHIBITS
Confidence: 95%
RELEASES
Confidence: 95%
RELEASES
Confidence: 95%
RELEASES
Confidence: 95%
CAUSES
Confidence: 95%
PROMOTES
Confidence: 95%
PROMOTES
Confidence: 95%
CAUSES
Confidence: 95%
PREVENTS
Confidence: 95%
ACTIVATES
Confidence: 95%
SUPPRESSES
Confidence: 95%
PROMOTES
Confidence: 95%
PREVENTS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree