aspirinaspirin activates SIRT1 deacetylaseSIRT1 deacetylates survivin(Lys129)survivin nuclear export and proteasomal degradation elevatedsurvivin loss destabilizes chromosomal passenger complex (CPC)XIAP(BIR2 domain) loses survivin-mediated stabilizationXIAP auto-ubiquitination by RING domain elevatedXIAP proteasomal degradation increasedcaspase-3(Asp175) and caspase-7(Asp198) no longer inhibited by XIAP BIR2caspase-3 active site accessible to substrate cleavageinflammation
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
ACETYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INDUCESConfidence: 95%
CAUSESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers