aspirinaspirin activates AMPK(Thr172) by raising AMP:ATP ratioAMPK phosphorylates TSC2(Ser1387) activating TSC1/TSC2 GAP complexRHEB-GTP hydrolysis to RHEB-GDP elevatedmTORC1(Raptor complex) kinase activity reducedULK1(Ser757) dephosphorylation releases mTORC1 inhibition of autophagyULK1(Ser317/Ser777) autophosphorylation activates autophagy initiationp62/SQSTM1 autophagic degradation elevatedp62 scaffold for TRAF6/IKKγ(NEMO) complex reducedIKKβ(Ser177/181) activation impairedNF-κB-driven IL-6 and TNF-α transcription suppressedinflammation Score: 0.9011 hops
Pathway Hops
PHOSPHORYLATESConfidence: 95%
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