Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1AXIN stabilized by AMPK-mediated phosphorylationβ-catenin(Ser33/Ser37/Thr41) phosphorylated by GSK-3β in destruction complexβ-catenin polyubiquitinated by β-TrCP/SCF complexβ-catenin proteasomal degradation elevatedTCF/LEF target gene transcription reducedc-Myc and cyclin D1 expression reducedCancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

PROMOTESConfidence: 95%

CAUSESConfidence: 95%

SUPPRESSESConfidence: 95%

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