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Biological Pathway
Cite
curcumin
curcumin inhibits JAK1/2(Tyr1034/Tyr1007) phosphorylation reducing IFN-γ-induced STAT1(Tyr701) activation
STAT1 binding to GAS element in CD274 (PD-L1) promoter reduced
PD-L1(CD274) surface expression on CRC cells reduced
PD-1(CD279) ligation on tumour-infiltrating CD8+ T cells reduced
SHP-2(Tyr580) recruitment to PD-1 ITSM motif reduced impairing TCR-ZAP70(Tyr315/319) dephosphorylation
CD8+ T cell cytotoxic activity restored elevating perforin/granzyme B release
granzyme B(Asp86) cleaves BID in CRC target cells initiating mitochondrial apoptosis
NK cell NKG2D ligand (MICA/MICB) expression on CRC cells elevated by curcumin-reduced shedding
NK cell-mediated ADCC-independent killing of CRC cells elevated
colorectal cancer
Score: 0.80
10 hops
Pathway Hops
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
ACETYLATES
Confidence: 95%
INHIBITS
Confidence: 95%
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
SUPPRESSES
Confidence: 95%
CAUSES
Confidence: 95%
INHIBITS
Confidence: 95%
INDUCES
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree