MetforminMetformin inhibits mitochondrial Complex I reducing electron fluxmitochondrial membrane potential (ΔΨm) depolarisedBAX(Ser184)-dephosphorylated inserts into OMM forming oligomeric porescytochrome c released from intermembrane spacecytochrome c binds APAF1(WD40 domain) relieving autoinhibitionAPAF1 oligomerises into heptameric apoptosome consuming dATPprocaspase-9 recruited via CARD-CARD interaction to apoptosomecaspase-9(Asp315) autoprocessing → active caspase-9caspase-9 cleaves procaspase-3 at Asp175caspase-3(Asp175)-cleaved executes PARP1(Asp214) cleavageCancer
Score: 0.8011 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INDUCESConfidence: 95%
CAUSESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
RECRUITSConfidence: 95%
ACTIVATESConfidence: 95%
CLEAVESConfidence: 95%
CLEAVESConfidence: 95%
PROMOTESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree