aspirinCOX-2(Ser516) acetylated by aspirinEPA oxygenated by acetylated-COX-2 to 18R-HEPE elevated18R-HEPE converted by 5-LOX to aspirin-triggered resolvin E1 (AT-RvE1) elevatedChemR23/CMKLR1 receptor activated on neutrophils and dendritic cellsPI3K(p85/p110) activation reducedRac1-GTP loading in neutrophils reducedtransendothelial neutrophil migration inhibitedIL-12 and TNF-α secretion by dendritic cells suppressedinflammation
Score: 0.909 hops
Pathway Hops
ACETYLATESConfidence: 95%
ACETYLATESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
ASSOCIATED WITHConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
SUPPRESSESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers