aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinTLR4/MD-2 complex activation by LPS attenuated by aspirin pre-treatmentMyD88 recruitment to TLR4 TIR domain reducedIRAK4(Thr345/Ser346) phosphorylation reducedTRAF6 K63-polyubiquitination reducedTAK1(Thr184/Thr187) phosphorylation reducedIKKβ(Ser177/Ser181) phosphorylation reducedNF-κB nuclear translocation suppressedIL-1β/TNF-α/CXCL8 secretion from macrophages reducedinflammation

Score: 0.809 hops

Pathway Hops

ACTIVATESConfidence: 95%

SUPPRESSESConfidence: 95%

CAUSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers