aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-2(Ser516) acetylation produces 18R-HEPE from EPA18R-HEPE converted to AT-resolvin D1 (AT-RvD1) by 5-LOXGPR32 (DRV1) receptor activated on macrophagesβ-arrestin-2 recruitment to GPR32ERK1/2(Thr202/Tyr204) phosphorylation reducedNLRP3 inflammasome assembly impairedcaspase-1(Cys285) autoprocessing reducedIL-1β(Asp116) maturation cleavage suppressedIL-18 secretion reducedinflammation

Score: 0.9010 hops

Pathway Hops

ACETYLATESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers