EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRRAS(GTP) elevated via SOS1-GRB2-EGFR complexCRAF(Ser338) phosphorylatedMEK1/2(Ser217/Ser221) phosphorylatedERK1/2(Thr202/Tyr204) phosphorylatedERK2 phosphorylates MCL-1(Thr163) stabilizing itMCL-1 ubiquitination by MULE E3 ligase reducedMCL-1 protein elevated at mitochondrial outer membraneBAK(Lys113) binding to MCL-1 maintainedcytochrome c release suppressedapoptosis

Score: 0.9010 hops

Pathway Hops

ASSOCIATED WITHConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers