Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membranehepatic gluconeogenesis reducedcirculating insulin levels reducedIGF-1 bioavailability reduced (elevated IGFBP-1)IGF-1R(Tyr1135/Tyr1136) autophosphorylation reducedIRS-1(Tyr612) phosphorylation reducedPI3K(p110α) recruitment to IRS-1 reducedAKT(Thr308/Ser473) phosphorylation reducedMDM2(Ser166) phosphorylation by AKT reducedp53 stabilization elevatedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers