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Biological Pathway
Cite
curcumin
JNK1/JNK2(Thr183/Tyr185) phosphorylation inhibited
c-Jun(Ser63/Ser73) phosphorylation reduced
AP-1 transcriptional complex assembly reduced
MMP-2 and MMP-9 transcription reduced
extracellular matrix degradation impaired
FAK(Tyr397) autophosphorylation reduced
integrin-mediated RHO-GTPase signaling reduced
F-actin cytoskeletal reorganization impaired
cancer cell migration and invasion reduced
colorectal cancer
Score: 0.90
10 hops
Pathway Hops
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
CAUSES
Confidence: 95%
INHIBITS
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
INDUCES
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree