aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinIKKβ(Ser1061/Thr847) acetylated by aspirinIKKβ kinase activity inhibitedIκBα(Ser32/Ser36) phosphorylation reducedIκBα degradation via SCF-βTrCP ubiquitination blockedNF-κB(p65) nuclear translocation inhibitedTNF-α/IL-1β/IL-6/ICAM-1 gene transcription reducedendothelial and macrophage pro-inflammatory activation suppressedinflammation

Score: 0.908 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers