aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-2(Ser516) acetylation by aspirin redirects arachidonic acid oxygenation15R-HETE generated instead of PGG215-epi-lipoxin A4 (15-epi-LXA4) biosynthesis elevatedFPR2/ALX receptor (FPRL1) activated on leukocytesGαi-mediated cAMP elevationPKA(Thr197) autophosphorylation activatedCREB(Ser133) phosphorylation elevatedMKP-1 (DUSP1) transcription upregulatedERK1/2(Thr202/Tyr204) dephosphorylation by MKP-1AP-1(c-Fos/c-Jun) transcriptional activity reducedCOX-2 and MMP-9 mRNA expression suppressedinflammation

Score: 0.9012 hops

Pathway Hops

ACETYLATESConfidence: 95%

CAUSESConfidence: 95%

UPREGULATESConfidence: 95%

ACTIVATESConfidence: 95%

SUPPRESSESConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

UPREGULATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers