EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR transactivates SRC kinase via direct phosphorylation of SRC(Tyr418)SRC(Tyr418) activatedSTAT3(Tyr705) phosphorylated by SRCSTAT3 nuclear translocationMCL-1 transcription elevated via STAT3 binding to MCL-1 promoterMCL-1 protein stabilized at mitochondriaNOXA displacement from MCL-1 impairedBAK activation suppressedcytochrome c release blockedapoptosis

Score: 0.9010 hops

Pathway Hops

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

PROMOTESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers