EGFREGFR activatedPI3K/AKT(Ser473) phosphorylatedTSC2(Thr1462) phosphorylatedTSC1/2 GAP activity inhibitedRHEB-GTP elevated → mTORC1(Raptor complex) activatedmTORC1 → ULK1(Ser757) phosphorylated → autophagy initiation suppressedEGFR inhibitionmTORC1 activity reducedULK1(Ser757) dephosphorylatedautophagy inducedautophagic degradation of BCL-2 via p62/SQSTM1 elevated → BCL-2 protein reducedBIM(EL) released from BCL-2 sequestration → BIM activates BAX at OMMcytochrome c released → APAF1 heptamer formed → caspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedapoptosis Score: 0.9015 hops
Pathway Hops
SUPPRESSESConfidence: 95%
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