EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR-bound GRB2-SOS activates KRASKRAS(GTP) activates PI3K p110α directlyAKT(Thr308/Ser473) phosphorylatedXIAP(Ser87) phosphorylated by AKTXIAP stabilized against auto-ubiquitinationXIAP BIR3 domain sequesters caspase-9XIAP BIR2 domain inhibits caspase-3(Asp175) cleavageeffector caspase activation blockedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers