EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRPI3K(p110α) activated by EGFRAKT(Thr308/Ser473) phosphorylatedFOXO3a(Thr32/Ser253/Ser315) phosphorylated by AKTFOXO3a sequestered by 14-3-3 proteins in cytoplasmFOXO3a nuclear import inhibitedBIM(EL) transcription reducedFasL transcription reducedmitochondrial outer membrane permeabilization impairedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

ACETYLATESConfidence: 95%

INHIBITSConfidence: 95%

ASSOCIATED WITHConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers