curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminmiR-21 biogenesis reduced by curcumin-mediated DROSHA complex inhibitionPTEN(Thr366) dephosphorylation-mediated stability elevatedPTEN lipid phosphatase activity elevatedPIP3 levels at membrane reducedAKT(Thr308/Ser473) phosphorylation reducedFOXO3a(Thr32) phosphorylation reducedFOXO3a nuclear translocation elevatedBIM and FASL transcription elevatedcaspase-8(Asp384) cleavage elevatedcolorectal cancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

CAUSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops