EGFRPI3K(p110α) activated downstream of EGFRAKT(Thr308/Ser473) phosphorylatedMDM2(Ser166/Ser186) phosphorylated by AKTMDM2 translocated to nucleusp53(Lys370/Lys372/Lys373) ubiquitinated by MDM2p53 targeted for proteasomal degradationPUMA and NOXA transcription reducedBAX homo-oligomerization at mitochondria impairedcytochrome c release blockedapoptosis
Score: 0.9010 hops
Pathway Hops
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
CAUSESConfidence: 95%
CAUSESConfidence: 95%
SUPPRESSESConfidence: 95%
PROMOTESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers