Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1RAPTOR(Ser792) phosphorylated by AMPKRAPTOR sequestered by 14-3-3 proteinsmTORC1 substrate recruitment impairedmTORC1 kinase activity inhibitedULK1(Ser317/Ser777) phosphorylated by AMPKautophagy flux elevatedmisfolded oncoproteins selectively degradedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

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