Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1PGC-1α(Ser177/Thr177) phosphorylated by AMPKPGC-1α transcriptional co-activator activity elevatedTFAM and NRF1 transcription elevatedmitochondrial biogenesis elevatedoxidative phosphorylation capacity restored in normal cellscancer cells with impaired PGC-1α unable to compensateselective energetic vulnerability of cancer cells elevatedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

ACTIVATESConfidence: 95%

PROMOTESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

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