curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcumincurcumin inhibits IKKβ(Ser177/181) phosphorylation reducing NF-κB-driven MYC transcriptioncurcumin reduces Wnt/β-catenin TCF4 occupancy at MYC promoter E-box (CACGTG) decreasing MYC mRNAMYC(Thr58) phosphorylation by GSK-3β (disinhibited by curcumin-reduced AKT) targets MYC for FBXW7 ubiquitin ligaseMYC polyubiquitination and proteasomal degradation elevatedMYC-driven ODC1 and cyclin D1(CCND1) transcription reducedcyclin D1 protein level reduced impairing CDK4/6 activityRB1(Ser780/Ser795) hypophosphorylation retains RB1–E2F1 repressor complexE2F1 target genes (PCNA, CDC6, MCM2) transcription reducedS-phase entry blocked and CRC proliferation reducedcolorectal cancer

Score: 0.9010 hops

Pathway Hops

PHOSPHORYLATESConfidence: 95%

PROMOTESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

PROMOTESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

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Pathway Hops

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Pathway Hops