aspirinCOX-2(Ser516) acetylated by aspirinarachidonic acid redirected to 15R-HETE synthesis15R-HETE converted by 5-LOX to 15-epi-lipoxin A4 (aspirin-triggered LXA4) elevatedFPR2/ALX receptor activatedPI3K/AKT(Ser473) phosphorylation in neutrophils elevatedPMN apoptosis acceleratedefferocytosis by macrophages enhancedpro-resolving mediator milieu establishedpro-inflammatory cytokine secretion reducedinflammation
Score: 0.9010 hops
Pathway Hops
ACETYLATESConfidence: 95%
INHIBITSConfidence: 95%
UPREGULATESConfidence: 95%
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INDUCESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
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