EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR activates SRC(Tyr418)SRC phosphorylates FAK(Tyr576/Tyr577) in kinase domainFAK(Tyr397) autophosphorylation recruits PI3K p85 subunitPI3K activated and PIP3 generatedAKT(Thr308/Ser473) phosphorylatedBAD(Ser136) phosphorylatedBCL-2 freed from BADcytochrome c release blockedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers