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Biological Pathway
Cite
curcumin
Smoothened(SMO) activity inhibited
GLI1 nuclear translocation impaired
GLI1-mediated transcription of PTCH1 and cyclin D1 reduced
cyclin D1/CDK4 complex formation reduced
RB(Ser780) hypophosphorylation maintained
E2F1-driven S-phase gene transcription reduced
DNA replication fork assembly impaired
cancer cell proliferation reduced
colorectal cancer
Score: 0.90
9 hops
Pathway Hops
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
CAUSES
Confidence: 95%
CAUSES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree