EGFRPLCγ1 activated by EGFR(pTyr992)IP3 generated and binds IP3R on ERCa2+ released from ER to cytoplasmcalmodulin (CaM) binds Ca2+ and activates CaMKIICaMKII(Thr286) autophosphorylatedBAD(Ser155) phosphorylated by CaMKIIBAD-BCL-2 interaction disruptedBCL-2 freed to suppress cytochrome c releaseapoptosis
Score: 0.909 hops
Pathway Hops
SUPPRESSESConfidence: 95%
ACTIVATESConfidence: 95%
BINDS TOConfidence: 95%
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
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