EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR activated → NF-κB(p65/p50) nuclear translocation elevatedNF-κB → c-FLIP(L) transcription upregulated → procaspase-8 displacement at DISCEGFR inhibition → c-FLIP(L) reduced → FAS(CD95) DISC assembly restoredFASL(CD95L) binds FAS → FADD recruited via DD-DED interactionprocaspase-8(Asp374/384) auto-cleaved at DISCcaspase-8 active → BID(Asp59) cleaved to tBIDtBID inserts into OMM → BAX/BAK pore formedcytochrome c released → caspase-9(Asp315) cleaved → caspase-3(Asp175) cleavedapoptosis

Score: 0.909 hops

Pathway Hops

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

INTERACTS WITHConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

INHIBITSConfidence: 95%

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