EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRTGF-β receptor transactivation ↑SMAD2/3 phosphorylation ↑SMAD4 complex formation ↑BIM transcription ↑BCL-2 inhibition ↑mitochondrial membrane permeabilization ↑caspase-9 activation ↑apoptosis

Score: 0.908 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers