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Biological Pathway
Cite
curcumin
curcumin inhibits GSK-3β(Tyr216) autophosphorylation reducing GSK-3β activity
MCL-1(Thr163) phosphorylation by GSK-3β reduced stabilising MCL-1 initially, but curcumin-induced NOXA elevation competes MCL-1 from BAK
BIM(Ser69) dephosphorylation by curcumin-reduced ERK activity stabilises BIM protein
BIM displaces BAX from BCL-XL sequestration
free BAX inserts into mitochondrial outer membrane
BAK(Tyr490) activation via BIM BH3-domain engagement
BAX/BAK pore formation elevates cytochrome c release
caspase-9(Asp315) activated via apoptosome
caspase-7(Asp198) cleaved executing apoptosis
colorectal cancer
Score: 0.80
10 hops
Pathway Hops
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INDUCES
Confidence: 95%
CAUSES
Confidence: 95%
ACTIVATES
Confidence: 95%
ACTIVATES
Confidence: 95%
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
INDUCES
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree