curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminJAK2(Tyr1007/Tyr1008) autophosphorylation inhibitedSTAT3(Tyr705) phosphorylation reducedSTAT3 dimerization impairedSTAT3 nuclear translocation blockedBCL-2, BCL-XL, and survivin transcription reducedmitochondrial membrane potential dissipatedcytochrome c releasedAPAF-1 apoptosome assembly activatedcaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedcolorectal cancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops