aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-2(Ser516) irreversibly acetylatedarachidonic acid conversion to PGH2 blockedPGE2 biosynthesis reducedEP2/EP4 receptor activation diminishedcAMP/PKA signaling in immune cells reducedCREB(Ser133) phosphorylation decreasedIL-6 and CXCL8 transcription suppressedleukocyte chemotaxis impairedinflammation

Score: 0.909 hops

Pathway Hops

ACETYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers