MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1NAD+/NADH ratio elevatedSIRT1 deacetylase activity elevatedp53(Lys382) deacetylation by SIRT1p53 transcriptional program altered toward cell cycle arrest genesCDKN1A (p21) and GADD45A elevatedDNA damage response amplified in tumor cellsCancer
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INDUCESConfidence: 95%
ACETYLATESConfidence: 95%
SUPPRESSESConfidence: 95%
ACTIVATESConfidence: 95%
INHIBITSConfidence: 95%
SUPPRESSESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree