Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1p53(Ser15) phosphorylated by AMPKMDM2-p53 interaction disruptedp53 transcriptional activity elevatedCDKN1A (p21CIP1) mRNA transcription elevatedCDK4/CDK6-cyclin D complexes inhibitedRB1 hypophosphorylation maintainedE2F target gene transcription repressedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

INCREASESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers