curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminHDAC1 and HDAC3 enzymatic activity inhibited by curcuminhistone H3(Lys9) acetylation elevated at CDKN1A promoterhistone H3(Lys27) trimethylation reduced at CDKN1A locusp21(WAF1/CIP1) transcription elevatedp21 binding to proliferating cell nuclear antigen (PCNA) elevatedDNA polymerase δ processivity reducedCDK4/cyclin D1 complex inhibited by p21G1 cell cycle arrest elevatedcolorectal cancer

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

ACETYLATESConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops