curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcumincurcumin inhibits PHD2(EGLN1) substrate competition reducing HIF-1α(Pro402/Pro564) hydroxylation protection — net effect: curcumin suppresses HIF-1α protein by blocking HSP90 chaperone interactionHIF-1α(Pro402) hydroxylation by PHD2 elevated under normoxia targets HIF-1α for VHL-E3 ubiquitin ligaseHIF-1α polyubiquitination and proteasomal degradation elevatedHIF-1α transactivation of VEGF-A promoter (HRE binding) reducedVEGF-A(165) secretion reduced impairing autocrine VEGFR2(Tyr1175) phosphorylationVEGFR2-PI3K-AKT(Ser473) pro-survival signalling reduced in tumour endotheliumtumour neoangiogenesis impaired reducing oxygen/nutrient delivery to CRC massGLUT1 transcription reduced impairing glycolytic flux in CRC cellsAMP/ATP ratio elevated activating AMPK(Thr172)AMPK phosphorylates TSC2(Ser1387) inhibiting mTORC1 and 4EBP1(Thr37/46) translationcolorectal cancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

SUPPRESSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

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Pathway Hops

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Pathway Hops