EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR kinase activates JAK2STAT3(Tyr705) phosphorylatedSTAT3 binds survivin promoter (−269 to −237 region)survivin (BIRC5) mRNA transcription elevatedsurvivin protein elevatedsurvivin associates with XIAP in chromosomal passenger complexcaspase-3 and caspase-7 catalytic activity inhibitedeffector caspase processing blockedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers