Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1SREBP1c(Ser372) phosphorylated by AMPKSREBP1c proteolytic processing by S1P/S2P inhibitednuclear SREBP1 levels reducedFASN and SCD1 transcription reducedunsaturated fatty acid supply for membrane biogenesis reducedcancer cell proliferation impairedCancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers