EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFREGFR activated → RAS(GTP-bound) elevatedRAS → CRAF(Ser338) phosphorylated → MEK1/2(Ser217/221) phosphorylatedERK1/2(Thr202/Tyr204) phosphorylated → RSK1(Ser380) activatedRSK1 → NOXA(BBC2) transcription via CREB(Ser133) phosphorylation elevatedNOXA protein elevated → MCL-1 BH3-binding groove occupiedMCL-1:BAK complex dissociated → BAK(Thr163) dephosphorylated → BAK activatedMOMP induced → cytochrome c releasedAPAF1 apoptosome assembled → caspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedapoptosis

Score: 0.9010 hops

Pathway Hops

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INTERACTS WITHConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers