curcuminIKKβ(Ser177/Ser181) autophosphorylation inhibited by curcuminIκBα(Ser32/Ser36) phosphorylation reducedIκBα ubiquitination by SCF-βTrCP E3 ligase impairedIκBα proteasomal degradation blockedNF-κB(p65/p50) nuclear translocation inhibitedBCL-2 and BCL-XL transcription reducedcytochrome c released from mitochondriacaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedcolorectal cancer
Score: 0.8010 hops
Pathway Hops
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
CAUSESConfidence: 95%
CAUSESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
INDUCESConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers