EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRSTAT3 homodimer translocates to nucleusDR5(TNFRSF10B) transcription suppressedEGFR inhibition → STAT3(Tyr705) dephosphorylated → DR5 promoter de-repressedDR5 surface expression elevated → TRAIL(TNFSF10) binding increasedDISC assembled with FADD → procaspase-8(Asp374/384) cleavedBID(Asp59) cleaved to tBID → BAX/BAK oligomerisation at OMMcytochrome c released → APAF1 apoptosome assembledcaspase-9(Asp315) activated → caspase-3(Asp175) cleavedapoptosis

Score: 0.809 hops

Pathway Hops

PHOSPHORYLATESConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

ASSOCIATED WITHConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers