curcuminPI3K(p110α) catalytic activity inhibitedAKT(Thr308/Ser473) phosphorylation reducedBAD(Ser136) phosphorylation by AKT reducedBAD dissociated from 14-3-3 proteinsBAD heterodimerizes with BCL-XL at mitochondrial membraneBCL-XL anti-apoptotic function neutralizedcytochrome c released from mitochondriacaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedcolorectal cancer
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PROMOTESConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
INDUCESConfidence: 95%
INHIBITSConfidence: 95%
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