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Biological Pathway
Cite
curcumin
GSK-3β(Tyr216) activating phosphorylation restored by curcumin
β-catenin(Ser33/Ser37/Thr41) phosphorylation elevated
β-catenin ubiquitinated by SCF-βTrCP complex
β-catenin proteasomal degradation elevated
TCF/LEF transcriptional activity reduced
c-Myc and cyclin D1 transcription reduced
G1/S cell cycle progression impaired
CDK4/CDK6 activity reduced
RB(Ser780) hypophosphorylation maintained
E2F1 transcriptional activity suppressed
colorectal cancer
Score: 0.90
11 hops
Pathway Hops
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
CAUSES
Confidence: 95%
CAUSES
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree