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Biological Pathway
Cite
curcumin
curcumin binds XIAP BIR2 domain inhibiting its interaction with caspase-3(Asp175)
curcumin reduces XIAP BIR3 domain occupancy releasing caspase-9(Asp315) inhibition
SMAC/DIABLO released from mitochondria competitively displaces XIAP via IBM–BIR3 binding
survivin(Thr34) phosphorylation by CDK1 reduced by curcumin destabilising the chromosomal passenger complex
survivin protein level reduced impairing its caspase-9 sequestration
cIAP1 auto-ubiquitination and proteasomal degradation elevated
RIPK1 de-ubiquitination shifts signalling toward caspase-8 activation
caspase-8(Asp374) cleavage elevated
caspase-3(Asp175) cleavage elevated
colorectal cancer
Score: 0.90
10 hops
Pathway Hops
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
BINDS TO
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
INDUCES
Confidence: 95%
INHIBITS
Confidence: 95%
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree